FP171ENDOCAPILLARY AND EXTRACAPILLARY HYPERCELLULARITY PROVIDE DIFFERENT OUTCOMES IN IGA NEPHROPATHY

Extracapillary proliferation in IgA nephropathy; recent findings and new ideas

CONTEXT IgA nephropathy (IgAN) is an autoimmune disorder and is the most common form of primary glomerulonephritis (GN) worldwide. EVIDENCE ACQUISITIONS Directory of Open Access Journals (DOAJ), Google Scholar, PubMed (NLM), LISTA (EBSCO) and Web of Science have been searched. RESULTS It is a slowly progressing disorder that leads to end-stage renal disease (ESRD) in up to 50% of the patien...

Significance of extracapillary proliferation in IgA-nephropathy patients with regard to clinical and histopathological variables.

BACKGROUND AND AIM Extracapillary proliferation (crescent) was not included in the Oxford classification, although previous attempts to correlate the crescent with clinical outcomes have produced conflicting results. In this study, we investigated the clinical and morphological significance of extracapillary proliferation in a group of IgA nephropathy (IgAN) patients with regard to the Oxford c...

IgA Nephropathy and Significance of Immunostaining Data

Clinical features and outcomes of IgA nephropathy with nephrotic syndrome.

BACKGROUND AND OBJECTIVES Nephrotic syndrome (NS) is a rare manifestation of IgA nephropathy (IgAN). Clinical characteristics and long-term outcomes of this condition have not yet been explored. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS A multicenter observational study was conducted between January 2000 and September 2010 in 1076 patients with biopsy-proven IgAN from four medical centers...

Association of C4d deposition with clinical outcomes in IgA nephropathy.

BACKGROUND AND OBJECTIVES Several studies have suggested that activation of the complement system is a contributing pathogenic mechanism in IgA nephropathy (IgAN). C4d staining is an inexpensive and easy-to-perform method for the analysis of renal biopsies. This study aimed to assess the clinical and prognostic implications of C4d staining in IgAN. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENT...